Syphilis in Kazakhstan will be treated according to a new clinical protocol

July 2, 2026

Kazakhstan has approved an updated clinical protocol for the diagnosis, treatment and prevention of syphilis, which complies with international standards. The document is aimed at improving medical care for patients, improving the quality of diagnosis, standardizing approaches to treatment, prevention of complications and prevention of congenital syphilis.

The clinical protocol combines the issues of diagnosis and treatment of early, late, congenital syphilis and preventive treatment. Previously, these areas were considered in separate clinical protocols. Combining them into one regulatory document will optimize the access of medical professionals to up-to-date information on various forms of the disease and ensure a unified approach to patient management, which is consistent with international practice.

The updated protocol details the diagnostic criteria for syphilis, including clinical, laboratory, and instrumental approaches. Special attention is paid to the mandatory examination of patients with a confirmed diagnosis of syphilis for HIV infection.

A separate important section of the protocol was post—exposure prophylaxis with doxycycline - DOXYPCP. The inclusion of this approach makes it possible to regulate the use of preventive measures, taking into account current data, as well as the need for the rational use of antibacterial drugs.

The protocol pays special attention to the management of pregnant women with syphilis. The document includes an algorithm for desensitization to penicillin in pregnant women with syphilis. This is of fundamental importance, since penicillin remains the only drug proven effective for the treatment of syphilis in pregnant women and the prevention of congenital syphilis.

The implementation of the protocol will improve the timeliness of syphilis detection, ensure the rational use of medicines, improve patient routing, and reduce the risk of adverse outcomes, including neurosyphilis, visual organ damage, sexual transmission, and cases of congenital syphilis.

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